Hypersensitivity Là Gì
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Affiliations
1 Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigsi mê và Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. ldelasvecillassanchezbwh.harvard.edu. 2 Department of Allergy, Marqués de Valdecilla University Hospital-IDIVAL, 39011 Santander, Spain. ldelasvecillassanchez
bwh.harvard.edu. 3 Division of Rheumatology, Immunology & Allergy, Department of Medicine, Brigđắm say và Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Leila_Alenazy
hms.harvard.edu. 4 Department of Medicine, College of Medicine, King Saud University, Riyadh 12372, Saudi Arabia. Leila_Alenazy
hms.harvard.edu. 5 Master of Medical Sciences in Immunology Program, Harvard Medical School, Boston, MA 02115, USA. Leila_Alenazy
hms.harvard.edu. 6 Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigđắm say và Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Marlene_Garcia-Neuer
dfci.harvard.edu. 7 Division of Rheumatology, Immunology và Allergy, Department of Medicine, Brigđê mê và Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. mcastells
Leticia de Las Vecillas Sánchez 1 2 ,Leila A Alenazy 3 4 5 ,Marlene Garcia-Neuer 6 ,Mariana C Castells 7
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Affiliations
1 Division of Rheumatology, Immunology & Allergy, Department of Medicine, Brigham và Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. ldelasvecillassanchezbwh.harvard.edu. 2 Department of Allergy, Marqués de Valdecilla University Hospital-IDIVAL, 39011 Santander, Spain. ldelasvecillassanchez
bwh.harvard.edu. 3 Division of Rheumatology, Immunology và Allergy, Department of Medicine, Brigyêu thích & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Leila_Alenazy
hms.harvard.edu. 4 Department of Medicine, College of Medicine, King Saud University, Riyadh 12372, Saudi Arabia. Leila_Alenazy
hms.harvard.edu. 5 Master of Medical Sciences in Immunology Program, Harvard Medical School, Boston, MA 02115, USA. Leila_Alenazy
hms.harvard.edu. 6 Division of Rheumatology, Immunology & Allergy, Department of Medicine, Brigđê mê và Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Marlene_Garcia-Neuer
dfci.harvard.edu. 7 Division of Rheumatology, Immunology & Allergy, Department of Medicine, Brigđắm đuối & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. mcastells
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Drug hypersensitivity reactions (HSRs) are increasing in the 21st Century with the ever expanding availability of new therapeutic agents. Patients with cancer, chronic inflammatory diseases, cystic fibrosis, or diabetes can become allergic to lớn their first line therapy after repeated exposures or through cross reactivity with environmental allergens. Avoidance of the offending allergenic drug may impact disease management, chất lượng of life, và life expectancy. Precision medicine provides new tools for the understanding & management of hypersensitivity reactions (HSRs), as well as a personalized treatment approach for IgE (Immunoglobuline E) and non-IgE mediated HSRs with drug desensitization (DS). DS induces a temporary hyporesponsive state by incremental escalation of sub-optimal doses of the offending drug. In vitro models have sầu shown evidence that IgE desensitization is an antigen-specific process which blocks calcium flux, impacts antigen/IgE/FcεRI complex internalization và prevents the axinh tươi và late phase reactions as well as mast cell mediator release. Through a "bench lớn bedside" approach, in vitro desensitization models help elucidate the molecular pathways involved in DS, providing new insights to lớn improved desensitization protocols for all patients. The ayên ổn of this Đánh Giá is lớn summarize up to date information on the drug HSRs, the IgE mediated mechanisms of desensitization, & their clinical applications.
Keywords: IgE; desensitization; desensitization models; drug hypersensitivity; high affinity IgE Fcε receptor I; mast cells; precision medicine.
